2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

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Chemical Name:2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid
CAS No.:950192-47-9
Molecular Formula:C₂₁H₂₅N₃O₃
Molecular Weight:367.448
Hs Code.:

Synonyms:2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

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Chemical Property of 2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

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Technology Process of 2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

There total 4 articles about 2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 950192-44-6
2(S)-[[(2-iodophenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

: 181219-01-2
4-pyridineboronic acid pinacol ester

: 950192-47-9
2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Microwaves;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 950192-47-9
2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 0.5 h / 0 - 20 °C

2: dichloromethane

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwaves

With pyridine; trifluoro-[1,3,5]triazine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 133010-05-6
tert-butyl 2-(fluorocarbonyl)pyrrolidine-1-carboxylate

: 950192-47-9
2(S)-[[(2-(4-pyridyl)phenyl)amino]carbonyl]-1-(1,1-dimethylethylester)-1-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.17 h / 130 °C / Microwaves

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;