(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

Base Information

Chemical Name:(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester
CAS No.:878270-14-5
Molecular Formula:C₁₅H₁₉I₂NO₅
Molecular Weight:547.129
Hs Code.:

Synonyms:(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

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Chemical Property of (S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

Chemical Property:

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Technology Process of (S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

There total 1 articles about (S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 183671-61-6
(S)-tert-butoxycarbonylamino(4-methoxyphenyl)acetic acid methyl ester

: 878270-14-5
(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

Guidance literature:: With N-iodo-succinimide; In acetone; at -79 - 20 ℃;
DOI:10.1021/jo051933m

Reference yield:

: 878270-14-5
(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

: (S)-Amino-(3,5-diiodo-4-methoxy-phenyl)-acetic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;
DOI:10.1021/jo051933m

Reference yield:

: 878270-14-5
(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

: C₄₈H₆₀I₄N₆O₁₆

Guidance literature:: Multi-step reaction with 5 steps

1: HCl / diethyl ether; CH₂Cl₂ / 20 °C

2: 1.08 g / DIPEA; BOP / dimethylformamide

3: HCl / diethyl ether; CH₂Cl₂ / 20 °C

4: 1.02 g / DIPEA; BOP / dimethylformamide

5: 24 percent / Pd(PPh₃)4; CuI; Et₃N / 1,1,2,2-tetrachloro-ethane / 16 h

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1,1,2,2-tetrachloroethane; 5: Sonogashira reaction;
DOI:10.1021/jo051933m