N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester
CAS No.:878270-17-8
Molecular Formula:C₂₁H₃₀I₂N₂O₆
Molecular Weight:660.288
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

Chemical Property:

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Technology Process of N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

There total 3 articles about N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878270-14-5
(S)-N-(tert-butyloxycarbonyl)-3,5-diiodo-4-methoxyphenylglycine methyl ester

: 878270-17-8
N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / diethyl ether; CH₂Cl₂ / 20 °C

2: 1.09 g / DIPEA; BOP / dimethylformamide

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo051933m

Reference yield:

: 183671-61-6
(S)-tert-butoxycarbonylamino(4-methoxyphenyl)acetic acid methyl ester

: 878270-17-8
N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / N-iodosuccinimide / acetone / -79 - 20 °C

2: HCl / diethyl ether; CH₂Cl₂ / 20 °C

3: 1.09 g / DIPEA; BOP / dimethylformamide

With hydrogenchloride; N-iodo-succinimide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo051933m

Reference yield:

: (S)-Amino-(3,5-diiodo-4-methoxy-phenyl)-acetic acid methyl ester; hydrochloride

: 16937-99-8,53296-34-7
N-Boc-D-Leu

: 878270-17-8
N-(tert-butyloxycarbonyl)-D-leucyl-(S-3,5-diiodo-4-methoxyphenylglycine) methyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jo051933m