N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide
CAS No.:1425485-85-3
Molecular Formula:C₁₈H₁₅F₂N₃O₃S
Molecular Weight:391.398
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

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Technology Process of N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

There total 12 articles about N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.7%

: 1428663-51-7
N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)-N-(propylsulfonyl)propane-1-sulfonamide

: 1425485-85-3
N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

Guidance literature:: With methanol; sodium hydroxide; at 20 ℃; for 1h;

Reference yield:

: 6925-00-4
quinoxaline-6-carboxylic acid

: 1425485-85-3
N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: hydrogenchloride; methanol / 3 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: methanol; sodium hydroxide / 1 h / 20 °C

With hydrogenchloride; methanol; n-butyllithium; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 875558-38-6
N-methoxy-N-methylquinoxaline-6-carboxamide

: 1425485-85-3
N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogenchloride; methanol / 3 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: methanol; sodium hydroxide / 1 h / 20 °C

With hydrogenchloride; methanol; n-butyllithium; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;