4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

Base Information

Chemical Name:4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl
CAS No.:1310036-96-4
Molecular Formula:C₂₀H₁₄BrF₃O
Molecular Weight:407.23
Hs Code.:

Synonyms:4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

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Chemical Property of 4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

Chemical Property:

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Technology Process of 4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

There total 7 articles about 4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.6%

: 1310037-04-7
[3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluoro-phenyl]-methanol

: 1310036-96-4
4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 6h;

Reference yield:

: 180636-50-4
methyl 4-fluoro-3-methylbenzoate

: 1310036-96-4
4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

Guidance literature:: Multi-step reaction with 6 steps

1: dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2: potassium carbonate / acetone / 6 h / Reflux

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 45 °C

4: lithium hydroxide / tetrahydrofuran / 6 h / Reflux

5: borane-THF / tetrahydrofuran / 4.33 h / 0 - 20 °C

6: phosphorus tribromide / dichloromethane / 6 h / 0 - 20 °C

With borane-THF; phosphorus tribromide; potassium carbonate; lithium hydroxide; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 403-15-6
4-fluoro-3-methyl-benzoic acid

: 1310036-96-4
4'-(5-bromomethyl-2-fluoro-benzyloxy)-2,4-difluoro-biphenyl

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogenchloride / water / 4 h / Reflux

2: dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

3: potassium carbonate / acetone / 6 h / Reflux

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 45 °C

5: lithium hydroxide / tetrahydrofuran / 6 h / Reflux

6: borane-THF / tetrahydrofuran / 4.33 h / 0 - 20 °C

7: phosphorus tribromide / dichloromethane / 6 h / 0 - 20 °C

With hydrogenchloride; borane-THF; phosphorus tribromide; potassium carbonate; lithium hydroxide; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;