3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Base Information

Chemical Name:3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester
CAS No.:1310037-00-3
Molecular Formula:C₂₁H₁₅F₃O₃
Molecular Weight:372.344
Hs Code.:

Synonyms:3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Suppliers and Price of 3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

There total 4 articles about 3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1306754-34-6
4-fluoro-3-(4-iodophenoxy)methylbenzoic acid methyl ester

: 144025-03-6
2,4-difluorophenylboronic acid

: 1310037-00-3
3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 45 ℃;

Reference yield:

: 878744-25-3
methyl 3-(bromomethyl)-4-fluorobenzoate

: 1310037-00-3
3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 45 °C

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 180636-50-4
methyl 4-fluoro-3-methylbenzoate

: 1310037-00-3
3-(2',4'-difluorobiphenyl-4-yloxymethyl)-4-fluorobenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2: potassium carbonate / acetone / 6 h / Reflux

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 45 °C

With potassium carbonate; dibenzoyl peroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrachloromethane; water; N,N-dimethyl-formamide; acetone;