5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Base Information

Chemical Name:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide
CAS No.:1184298-09-6
Molecular Formula:C₂₆H₂₉ClN₄O₆S₂
Molecular Weight:593.124
Hs Code.:

Synonyms:5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

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Chemical Property of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

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Technology Process of 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

There total 10 articles about 5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1184298-06-3
5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

: 1184298-09-6
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Guidance literature:: 5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride; With sodium hydroxide; In dichloromethane; water;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 17h;

Reference yield:

: 42518-98-9
5-chlorothiophene-2-carbonyl chloride

: 1184298-09-6
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

3.1: boron tribromide / dichloromethane / 0 °C

3.2: 0.25 h / 20 °C / Saturated solution

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane

5.1: sodium hydroxide / dichloromethane; water

5.2: 17 h

With boron tribromide; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In dichloromethane; water;

Reference yield:

: 1184297-37-7
[(S)-1-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-2-((S)-3-methyl-morpholin-4-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 1184298-09-6
5-chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(1-oxy-pyridin-2-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / 0 °C

1.2: 0.25 h / 20 °C / Saturated solution

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane

3.1: sodium hydroxide / dichloromethane; water

3.2: 17 h

With boron tribromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water;