5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

Base Information

Chemical Name:5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride
CAS No.:1184298-06-3
Molecular Formula:C₂₆H₂₉ClN₄O₅S₂*ClH
Molecular Weight:613.586
Hs Code.:

5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

Synonyms:5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

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Chemical Property of 5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

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Technology Process of 5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

There total 9 articles about 5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1184298-08-5
2-ethyl-3-pyridin-2-yl-benzenesulfonyl chloride

: 1184297-38-8
5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

: 1184298-06-3
5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: 2-ethyl-3-pyridin-2-yl-benzenesulfonyl chloride; 5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 42518-98-9
5-chlorothiophene-2-carbonyl chloride

: 1184298-06-3
5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C

3.1: boron tribromide / dichloromethane / 0 °C

3.2: 0.25 h / 20 °C / Saturated solution

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With boron tribromide; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane;

Reference yield:

: 1184297-37-7
[(S)-1-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-2-((S)-3-methyl-morpholin-4-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

: 1184298-06-3
5-chloro-thiophene-2-carboxylic acid[(S)-2-(2-ethyl-3-pyridin-2-yl-benzene-sulfonylamino)-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 0 °C

1.2: 0.25 h / 20 °C / Saturated solution

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With boron tribromide; N-ethyl-N,N-diisopropylamine; In dichloromethane;