N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

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Chemical Name:N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide
CAS No.:871339-80-9
Molecular Formula:C₂₁H₂₇F₆N₅O₂
Molecular Weight:495.468
Hs Code.:

Synonyms:N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

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Chemical Property of N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

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Technology Process of N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

There total 7 articles about N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 871339-79-6
1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

: 871339-80-9
N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

Guidance literature:: 1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3.5h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 871339-72-9
phenylmethyl 3,5-dibromo-4-methylbenzoate

: 871339-80-9
N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / 3 h

5.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2.5 h / 0 °C

6.1: sodium azide / dichloromethane / 3 h / 0 °C

7.1: toluene / 2 h / 100 °C

8.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

With pyridine; sodium azide; trifluoro-[1,3,5]triazine; hydrogen; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;

Reference yield:

: 871339-73-0
1,1-dimethylethyl 4-(3-bromo-2-methyl-5-{[(phenylmethyl)oxy]carbonyl}phenyl)piperazine-1-carboxylate

: 871339-80-9
N-{5-amino-2-methyl-3-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}-2,2,2-trifluoro-N-(2-pyrrolidin-1-ylethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.2: 1.5 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / 3 h

4.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2.5 h / 0 °C

5.1: sodium azide / dichloromethane / 3 h / 0 °C

6.1: toluene / 2 h / 100 °C

7.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C

With pyridine; sodium azide; trifluoro-[1,3,5]triazine; hydrogen; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;