1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

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Chemical Name:1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate
CAS No.:871339-79-6
Molecular Formula:C₂₆H₃₅F₆N₅O₄
Molecular Weight:595.585
Hs Code.:

Synonyms:1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

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Chemical Property of 1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

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Technology Process of 1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

There total 7 articles about 1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 871339-78-5
4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoyl azide

: 75-65-0
tert-butyl alcohol

: 871339-79-6
1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

Guidance literature:: In toluene; at 100 ℃; for 2h;

Reference yield:

: 871339-72-9
phenylmethyl 3,5-dibromo-4-methylbenzoate

: 871339-79-6
1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

4.1: hydrogen / palladium 10% on activated carbon / 3 h

5.1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2.5 h / 0 °C

6.1: sodium azide / dichloromethane / 3 h / 0 °C

7.1: toluene / 2 h / 100 °C

With pyridine; sodium azide; trifluoro-[1,3,5]triazine; hydrogen; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;

Reference yield:

: 871339-75-2
phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

: 871339-79-6
1,1-dimethylethyl {4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / 3 h

2: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2.5 h / 0 °C

3: sodium azide / dichloromethane / 3 h / 0 °C

4: toluene / 2 h / 100 °C

With pyridine; sodium azide; trifluoro-[1,3,5]triazine; hydrogen; palladium 10% on activated carbon; In dichloromethane; toluene;