Telmesteine

Base Information

• Chemical Name: Telmesteine
• CAS No.: 122946-43-4
• Molecular Formula: C7H11NO4S
• Molecular Weight: 205.235
• Hs Code.: 2934999090
• UNII: 124I3FE35T
• DSSTox Substance ID: DTXSID60153804
• Nikkaji Number: J561.874F
• Wikidata: Q27251366
• NCI Thesaurus Code: C74550
• ChEMBL ID: CHEMBL2107621
• Mol file: 122946-43-4.mol

Synonyms:3-ethylhydrogen-3,4-thiazolidinedicarboxylate;telmestein;telmesteine

Chemical Property of Telmesteine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 98oC
• Refractive Index: 1.562
• Boiling Point: 386.2 °C at 760 mmHg
• Flash Point: 187.4 °C
• PSA: 92.14000
• Density: 1.409 g/cm³
• LogP: 0.54030
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 205.04087901
• Heavy Atom Count: 13
• Complexity: 221

Purity/Quality:

98%Min ^*data from raw suppliers

(4R)-3-(ETHOXYCARBONYL)-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)N1CSCC1C(=O)O
• Isomeric SMILES: CCOC(=O)N1CSC[C@H]1C(=O)O
• Description: Telmesteine is a new mucolytic agent possessing expectorant and secretolytic activity introduced for the treatment of acute and chronic bronchitis. It is reported to have anti-elastase activity and to show effectiveness in pulmonary emphysema.
• Uses: Telmesteine is a useful agent for respiratory tract disorders; also it has been reported to be a critical active ingredient in topical compositions for dermatitis.

Technology Process of Telmesteine

There total 2 articles about Telmesteine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroformic acid ethyl ester (541-41-3) + L-thioproline (34592-47-7,2756-91-4,6070-92-4,60731-25-1) → telmesteine (122946-43-4,127657-29-8)

Guidance literature:

With TEA; water; In acetone; at 0 ℃; for 0.75h;

DOI:10.1055/s-1999-3488

Reference yield:

chloroformic acid ethyl ester (541-41-3) → telmesteine (122946-43-4,127657-29-8)

Guidance literature:

With water;

Reference yield: 20.0%

telmesteine (122946-43-4,127657-29-8) + C9H11NO4 → C16H20N2O7S

Guidance literature:

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

chloroformic acid ethyl ester

L-thioproline