dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

Base Information

Chemical Name:dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate
CAS No.:553679-23-5
Molecular Formula:C₂₇H₃₄F₃NO₈
Molecular Weight:557.564
Hs Code.:

dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

Synonyms:dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

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Chemical Property of dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

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Technology Process of dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

There total 3 articles about dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 270925-36-5
dimethyl (2S)-2-[N-((1R)-1-phenylethyl)-2,2,2-trifluoroacetylamino]-4-oxopentane-1,5-dioate

: 553679-22-4
(4S)-4-[(1Z)-3-(bromomethyl)buta-1,3-dienyl]-2,2-dimethyl-1,3-dioxolane

: 553679-23-5
dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

Guidance literature:: With indium; water; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: (4S)-4-(3-methylbuta-1,3-dienyl)-2,2-dimethyl-1,3-dioxolane

: 553679-23-5
dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

Guidance literature:: Multi-step reaction with 3 steps

1: 25 percent / SeO₂; t-BuOOH / CH₂Cl₂ / 24 h / 0 °C

2: 60 percent / PPh₃; NBS / CH₂Cl₂ / 0.5 h / 0 °C

3: 72 percent / indium; H₂O / tetrahydrofuran / 16 h / 20 °C

With tert.-butylhydroperoxide; indium; N-Bromosuccinimide; selenium(IV) oxide; water; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 553679-21-3
4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-en-1-ol

: 553679-23-5
dimethyl 4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}-2-[4-[(4S)-2,2-dimethyl(1,3-dioxolan-4-yl)](3Z)-2-methylenebut-3-enyl] (2S,4S)-2-hydroxypentane-1,5-dioate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / PPh₃; NBS / CH₂Cl₂ / 0.5 h / 0 °C

2: 72 percent / indium; H₂O / tetrahydrofuran / 16 h / 20 °C

With indium; N-Bromosuccinimide; water; triphenylphosphine; In tetrahydrofuran; dichloromethane;