dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

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Chemical Name:dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate
CAS No.:553679-28-0
Molecular Formula:C₃₈H₄₀F₃NO₁₂S
Molecular Weight:791.796
Hs Code.:

dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

Synonyms:dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

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Chemical Property of dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

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Technology Process of dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

There total 9 articles about dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 98-88-4
benzoyl chloride

: 553679-27-9
dimethyl 2-[2-(3-{(1R)-1-hydroxy-2-[(4-methylphenyl)sulfonyloxy]ethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

: 553679-28-0
dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

Guidance literature:: With pyridine; at 0 ℃; for 2h;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 553679-28-0
dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / pyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 48 h / 20 °C

2: 70 percent / MCPBA; NaHCO₃ / benzene / 12 h / 10 °C

3: 95 percent / pyridine / 2 h / 0 °C

With pyridine; 4 A molecular sieve; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; benzene;

Reference yield:

: 270925-36-5
dimethyl (2S)-2-[N-((1R)-1-phenylethyl)-2,2,2-trifluoroacetylamino]-4-oxopentane-1,5-dioate

: 553679-28-0
dimethyl 2-[2-(3-{(1R)-2-[(4-methylphenyl)sulfonyloxy]-1-phenylcarbonyloxyethyl}(2R,3R)oxiran-2-yl)prop-2-enyl]-4-{N-[(1R)-1-phenylethyl]-2,2,2-trifluoroacetylamino}(2S,4S)-2-hydroxypentane-1,5-dioate

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / indium; H₂O / tetrahydrofuran / 16 h / 20 °C

2: 95 percent / aq. HCl / tetrahydrofuran / 5 h / 20 °C

3: 80 percent / pyridine; 4 Angstroem molecular sieves / CH₂Cl₂ / 48 h / 20 °C

4: 70 percent / MCPBA; NaHCO₃ / benzene / 12 h / 10 °C

5: 95 percent / pyridine / 2 h / 0 °C

With pyridine; hydrogenchloride; indium; 4 A molecular sieve; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; benzene;