O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

Base Information

Chemical Name:O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine
CAS No.:150884-13-2
Molecular Formula:C₄₀H₅₀N₂O₇Si
Molecular Weight:698.932
Hs Code.:

O<sup>4</sup>-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

Synonyms:O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

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Technology Process of O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

There total 3 articles about O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-18-6
allyl alcohol

: 2,4,6-Trimethyl-benzenesulfonic acid 1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

: 150884-13-2
O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

Guidance literature:: With 5-bromo-2'-deoxyuridine; trimethylamine; In dichloromethane; at 0 ℃; for 10h; Yield given;
DOI:10.1021/jo00072a050

Reference yield:

: 107-18-6
allyl alcohol

: Toluene-4-sulfonic acid 1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

: 150884-13-2
O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1021/acsmedchemlett.0c00232

Reference yield:

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: 150884-13-2
O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: trimethylamine, BDU / CH₂Cl₂ / 10 h / 0 °C

With dmap; 5-bromo-2'-deoxyuridine; triethylamine; trimethylamine; In dichloromethane;
DOI:10.1021/jo00072a050