4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

Base Information

Chemical Name:4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide
CAS No.:1070889-97-2
Molecular Formula:C₂₄H₂₂ClN₃O₃
Molecular Weight:435.91
Hs Code.:

Synonyms:4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

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Chemical Property of 4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

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Technology Process of 4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

There total 11 articles about 4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1070889-97-2
4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen bromide; bromine; sodium nitrite / water / 1 h / 0 - 5 °C

1.2: 20 °C / pH ~ 13

2.1: n-butyllithium / toluene; pentane / 2 h / -78 °C

2.2: 1 h / -78 °C

2.3: -10 °C

3.1: trichlorophosphate / toluene / 5 h / Heating / reflux

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

With n-butyllithium; hydrogen bromide; bromine; potassium carbonate; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; pentane;

Reference yield:

: 1070889-90-5
4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-(2-hydroxy-phenyl)-N-methyl-benzamide

: 627-18-9
1-bromo-3-propanol

: 1070889-97-2
4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

: 42860-10-6
3-bromo-4-chlorobenzoic acid

: 1070889-97-2
4-chloro-3-(6-cyano-4-methyl-pyridin-3-yl)-N-[2-(3-hydroxy-propoxy)-phenyl]-N-methyl-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

2.1: sodium hydrogencarbonate / water; acetonitrile / 1.5 h

2.2: 16 h / 20 °C

3.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 14 h / 95 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C

With oxalyl dichloride; potassium acetate; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;