(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

Base Information

Chemical Name:(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate
CAS No.:1257387-90-8
Molecular Formula:C₂₆H₃₆F₂N₂O₅
Molecular Weight:494.579
Hs Code.:

Synonyms:(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

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Chemical Property of (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

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Technology Process of (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

There total 8 articles about (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1257387-89-5
(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-3-oxopiperazine-1-carboxylate

: 96-32-2
bromoacetic acid methyl ester

: 1257387-90-8
(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-3-oxopiperazine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

bromoacetic acid methyl ester; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 220607-75-0
2-bromo-1-(3,5-difluorophenyl)ethanone

: 1257387-90-8
(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride / methanol; water / 20 °C

2.1: potassium carbonate / tetrahydrofuran / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 50 °C / 2587.76 Torr / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 20 °C

With hydroxylamine hydrochloride; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 226723-95-1
cycloheptylmethyl iodide

: 1257387-90-8
(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -50 °C

1.2: -78 - 20 °C

1.3: 0.33 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 100 °C

3.1: potassium carbonate / tetrahydrofuran / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 50 °C / 2587.76 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 20 °C

With n-butyllithium; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;