2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

Base Information

Chemical Name:2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid
CAS No.:1257387-91-9
Molecular Formula:C₂₅H₃₄F₂N₂O₅
Molecular Weight:480.552
Hs Code.:

Synonyms:2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

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Chemical Property of 2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

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Technology Process of 2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

There total 9 articles about 2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1257387-90-8
(2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate

: 1257387-91-9
2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

Guidance literature:: (2S)-tert-butyl-2-(cycloheptylmethyl)-5-(3,5-difluorophenyl)-4-(2-methoxy-2-oxoethyl)-3-oxopiperazine-1-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 220607-75-0
2-bromo-1-(3,5-difluorophenyl)ethanone

: 1257387-91-9
2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine hydrochloride / methanol; water / 20 °C

2.1: potassium carbonate / tetrahydrofuran / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 50 °C / 2587.76 Torr / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

5.2: 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 2 h

With hydroxylamine hydrochloride; water; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 226723-95-1
cycloheptylmethyl iodide

: 1257387-91-9
2-((3S)-4-(tert-butoxycarbonyl)-3-(cycloheptylmethyl)-6-(3,5-difluorophenyl)-2-oxopiperazin-1-yl)ethanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -50 °C

1.2: -78 - 20 °C

1.3: 0.33 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / 100 °C

3.1: potassium carbonate / tetrahydrofuran / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 50 °C / 2587.76 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 20 °C

7.1: water; lithium hydroxide / tetrahydrofuran / 2 h

With n-butyllithium; water; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; acetonitrile;