(Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester

Base Information

• Chemical Name: (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester
• CAS No.: 204325-22-4
• Molecular Formula: C₃₀H₄₀O₃Si
• Molecular Weight: 476.731
• Mol file: 204325-22-4.mol

Synonyms:(Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester

Chemical Property of (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester

There total 6 articles about (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,3,5-Trioxan (110-88-3) + (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-non-5-enoic acid methyl ester → (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester (204325-22-4)

Guidance literature:

With sodium hydride;

DOI:10.1039/a707320h

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester (204325-22-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / imidazole

2: 64 percent / NIS, PPh₃ / CH₂Cl₂ / -30 °C

3: 73 percent / NaH / dimethylsulfoxide

4: 85 percent / NaH

With 1H-imidazole; N-iodo-succinimide; sodium hydride; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/a707320h

Reference yield:

dicyclopropyl ketone (1121-37-5) → (Z)-9-(tert-Butyl-diphenyl-silanyloxy)-6-cyclopropyl-2-methylene-non-5-enoic acid methyl ester (204325-22-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) MeMgBr, Mg / 1.) THF, -30 deg C; 70 deg C

2: 97 percent / imidazole

3: 64 percent / NIS, PPh₃ / CH₂Cl₂ / -30 °C

4: 73 percent / NaH / dimethylsulfoxide

5: 85 percent / NaH

With 1H-imidazole; N-iodo-succinimide; methylmagnesium bromide; sodium hydride; magnesium; triphenylphosphine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1039/a707320h

upstream raw materials:

1,3,5-Trioxan

tert-butylchlorodiphenylsilane

dicyclopropyl ketone

1,1-Dicyclopropyl-butane-1,4-diol

Downstream raw materials:

(2Z,6Z)-6-Cyclopropyl-10-methylene-2-(3-phenylselanylcarbonyl-propyl)-undeca-2,6-dienedioic acid dimethyl ester

(2Z,6Z)-2-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-6-cyclopropyl-10-methylene-undeca-2,6-dienedioic acid dimethyl ester