6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol

Base Information

• Chemical Name: 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol
• CAS No.: 128329-63-5
• Molecular Formula: C₂₄H₃₆O₂Si
• Molecular Weight: 384.634
• Mol file: 128329-63-5.mol

Synonyms:6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol

Chemical Property of 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol

There total 23 articles about 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2R,4S)-2,4-dimethyl-1-<(tert-butyldiphenylsilyl)oxy>hex-5-ene (129032-45-7) → 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol (128329-63-5)

Guidance literature:

(2R,4S)-2,4-dimethyl-1-<(tert-butyldiphenylsilyl)oxy>hex-5-ene; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2015.08.011

Reference yield: 71.0%

(2S,4S)-2,4-dimethyl-1-(tert-butyldiphenylsilyloxy)-5-hexene (320742-72-1) → (3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexan-1-ol (128329-63-5)

Guidance literature:

(2S,4S)-2,4-dimethyl-1-(tert-butyldiphenylsilyloxy)-5-hexene; With dimeric 9-borabicyclo[3.3.1]nonane; In tetrahydrofuran; for 0.666667h; sonication;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at -5 ℃; Further stages.;

DOI:10.1016/j.tet.2004.06.014

Reference yield: 71.0%

(R)-3-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexanoyl)-4-phenyloxazolidin-2-one → 6-[[(tert-butyl)diphenylsilyl]oxy]-(3S,5R)-3,5-dimethyl-hexan-1-ol (128329-63-5)

Guidance literature:

With lithium borohydride; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo201951s

upstream raw materials:

(4R,1E)-4,6-dimethyl-7-((1,1-dimethylethenyl)diphenylsiloxy)-1-phenyl-1-heptene

(4R,6E)-2,4-dimethyl-7-phenyl-6-hepten-1-ol

(4R,6E)-2,4-dimethyl-7-phenyl-6-heptenoic acid

(2S,4'R,6'E)-1-(2',4'-dimethyl-7'-phenyl-6'-heptenoyl)-2-(hydroxymethyl)pyrrolidine

Downstream raw materials:

tert-Butyl-((2R,4S)-2,4-dimethyl-6-phenylsulfanyl-hexyloxy)-diphenyl-silane

((2R,4S)-6-azido-2,4-dimethylhexyloxy)(tert-butyl)diphenylsilane

(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide

(R)-N-((3S,5R)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-N,2-dimethylbutanamide