ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate

Base Information

• Chemical Name: ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate
• CAS No.: 1447797-51-4
• Molecular Formula: C₂₀H₂₀ClNO₃
• Molecular Weight: 357.837
• Mol file: 1447797-51-4.mol

Synonyms:ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate

Chemical Property of ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate

There total 4 articles about ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester (52906-62-4) + o-Methoxybenzyl bromide (52289-93-7) → ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate (1447797-51-4)

Guidance literature:

3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester; With sodium hydride; In tetrahydrofuran; for 0.25h; Inert atmosphere;

o-Methoxybenzyl bromide; In tetrahydrofuran; at 35 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja4050168

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate (1447797-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-diamino-benzene; rac-Pro-OH / ethanol / 16 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere

2.2: 16 h / 35 °C / Inert atmosphere

With sodium hydride; 1,2-diamino-benzene; rac-Pro-OH; In tetrahydrofuran; ethanol;

DOI:10.1021/ja4050168

Reference yield:

4-chlorobenzaldehyde (104-88-1) → ethyl 2-(4-chlorobenzyl)-2-cyano-3-(2-methoxyphenyl)propanoate (1447797-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,2-diamino-benzene; rac-Pro-OH / ethanol / 16 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere

2.2: 16 h / 35 °C / Inert atmosphere

With sodium hydride; 1,2-diamino-benzene; rac-Pro-OH; In tetrahydrofuran; ethanol;

DOI:10.1021/ja4050168

upstream raw materials:

3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

o-Methoxybenzyl bromide

ethyl 2-cyanoacetate

4-chlorobenzaldehyde

Downstream raw materials:

ethyl 2-cyano-3-phenylpropanoate

ethyl 2-cyano-3-(2-methoxyphenyl)propanoate

3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester