N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide

Base Information

• Chemical Name: N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide
• CAS No.: 179945-88-1
• Molecular Formula: C₂₀H₂₅NO₃S
• Molecular Weight: 359.489
• Mol file: 179945-88-1.mol

Synonyms:N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide

Chemical Property of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide

There total 2 articles about N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Ethylsulfanylmethyl-benzoic acid (79313-52-3) → N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide (179945-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 1 h / Ambient temperature

2: 7.8 g / CH₂Cl₂ / 2 h / Ambient temperature

With thionyl chloride; In dichloromethane; benzene;

DOI:10.1021/jo9716183

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + 2-Ethylsulfanylmethyl-benzoyl chloride → N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide (179945-88-1)

Guidance literature:

In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jo9716183

Reference yield: 83.0%

3-(methoxycarbonyl)but-3-enoyl chloride + N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide (179945-88-1) → 4-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-4-oxo-butyric acid methyl ester (179945-91-6)

Guidance literature:

With 4A MS; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo9716183

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

2-Ethylsulfanylmethyl-benzoic acid

Downstream raw materials:

N-But-3-enoyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide

4-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-4-oxo-butyric acid methyl ester

5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester

N-But-3-enoyl-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-2-ethanesulfinylmethyl-benzamide