5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester

Base Information

• Chemical Name: 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester
• CAS No.: 202391-98-8
• Molecular Formula: C₂₇H₃₃NO₆S
• Molecular Weight: 499.628
• Mol file: 202391-98-8.mol

Synonyms:5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester

Chemical Property of 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester

There total 3 articles about 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-methoxycarbonylpent-4-enoyl chloride + N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide (179945-88-1) → 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester (202391-98-8)

Guidance literature:

With 4A MS; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1021/jo9716183

Reference yield:

2-Ethylsulfanylmethyl-benzoic acid (79313-52-3) → 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester (202391-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / benzene / 1 h / Ambient temperature

2: 7.8 g / CH₂Cl₂ / 2 h / Ambient temperature

3: 76 percent / 4A MS / CH₂Cl₂ / 24 h / Ambient temperature

With thionyl chloride; In dichloromethane; benzene;

DOI:10.1021/jo9716183

Reference yield:

2-Ethylsulfanylmethyl-benzoyl chloride → 5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethylsulfanylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester (202391-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 7.8 g / CH₂Cl₂ / 2 h / Ambient temperature

2: 76 percent / 4A MS / CH₂Cl₂ / 24 h / Ambient temperature

With 4A MS; In dichloromethane;

DOI:10.1021/jo9716183

upstream raw materials:

N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-ethylsulfanylmethyl-benzamide

2-Ethylsulfanylmethyl-benzoic acid

Downstream raw materials:

5-[[2-(3,4-Dimethoxy-phenyl)-ethyl]-(2-ethanesulfinylmethyl-benzoyl)-amino]-2-methylene-5-oxo-pentanoic acid methyl ester