(2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Base Information

Chemical Name:(2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal
CAS No.:133782-37-3
Molecular Formula:C₂₀H₃₄O₄Si
Molecular Weight:366.573
Hs Code.:

Synonyms:(2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Suppliers and Price of (2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

There total 26 articles about (2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 133782-37-3
(2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / NaI, Proton Sponge / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

2: 86 percent / MeLi / diethyl ether / 0.5 h / 0 °C

3: 1.) (SOCl)2, DMSO, 2.) pyridine / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) CH₂Cl₂, from -60 deg C to RT, 1 h

With pyridine; thionyl chloride; Proton Sponge; methyllithium; dimethyl sulfoxide; sodium iodide; In 1,2-dimethoxyethane; diethyl ether;
DOI:10.1021/ja00090a016

Reference yield:

: 96481-55-9,2088-07-5
2-methylpent-1-en-3-ol

: 133782-37-3
(2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Ti(O-i-Pr)4, t-BuOOH, 4A-molecular sieves, diisopropyl D-tartarate / 1.) CH₂Cl₂, 2,2,4-trimethylpentane, -20 deg C, 30 min, 2.) CH₂Cl₂, 2,2,4-trimethylpentane, -20 deg C, 11 h

2: 63 percent / Ti(O-i-Pr)4 / CH₂Cl₂ / 40 h / Ambient temperature

3: 80 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -20 °C

4: 84 percent / NaI, Proton Sponge / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

5: 86 percent / MeLi / diethyl ether / 0.5 h / 0 °C

6: 1.) (SOCl)2, DMSO, 2.) pyridine / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) CH₂Cl₂, from -60 deg C to RT, 1 h

With pyridine; 2,6-dimethylpyridine; titanium(IV) isopropylate; tert.-butylhydroperoxide; thionyl chloride; Proton Sponge; 4 A molecular sieve; methyllithium; D-(-)-diisopropyl tartrate; dimethyl sulfoxide; sodium iodide; In 1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1021/ja00090a016

Reference yield:

: 159170-70-4
(2S,3R)-1,2-epoxy-2-methylpentan-3-ol

: 133782-37-3
(2S,3R)-2-<(benzyloxy)methoxy>-3-<(tert-butyldimethylsilyl)oxy>-2-methylpentanal

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / Ti(O-i-Pr)4 / CH₂Cl₂ / 40 h / Ambient temperature

2: 80 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -20 °C

3: 84 percent / NaI, Proton Sponge / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

4: 86 percent / MeLi / diethyl ether / 0.5 h / 0 °C

5: 1.) (SOCl)2, DMSO, 2.) pyridine / 1.) CH₂Cl₂, -60 deg C, 15 min, 2.) CH₂Cl₂, from -60 deg C to RT, 1 h

With pyridine; 2,6-dimethylpyridine; titanium(IV) isopropylate; thionyl chloride; Proton Sponge; methyllithium; dimethyl sulfoxide; sodium iodide; In 1,2-dimethoxyethane; diethyl ether; dichloromethane;
DOI:10.1021/ja00090a016