diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

Base Information

Chemical Name:diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate
CAS No.:1584736-48-0
Molecular Formula:C₂₇H₂₁ClNO₄PS
Molecular Weight:521.961
Hs Code.:

Synonyms:diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

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Technology Process of diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

There total 6 articles about diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1403781-79-2
diphenyl (isothiocyanato(phenyl)methyl)phosphonate

: 104-88-1
4-chlorobenzaldehyde

: 1584736-48-0
diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

Guidance literature:: With C₃₂H₂₈F₆N₄O₃; In Dimethyl ether; at 30 ℃; for 48h;
DOI:10.1002/anie.201308514

Reference yield:

: 100-52-7
benzaldehyde

: 1584736-48-0
diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium hydroxide / water / 48 h / 20 °C

2.1: chloroform / Reflux

3.1: tetrahydrofuran / 4 h / 0 °C

4.1: ammonium hydroxide / water / 0.33 h / 20 °C

5.1: triethylamine; carbon disulfide / dichloromethane / 2 h / 0 °C

5.2: 2 h / 20 °C

6.1: C₃₂H₂₈F₆N₄O₃ / Dimethyl ether / 48 h / 30 °C

With carbon disulfide; ammonium hydroxide; C₃₂H₂₈F₆N₄O₃; triethylamine; In tetrahydrofuran; Dimethyl ether; dichloromethane; chloroform; water; 6.1: |Aldol Addition;
DOI:10.1002/anie.201308514

Reference yield:

: 871315-40-1
C₂₆H₂₂NO₃P

: 1584736-48-0
diphenyl ((4R,5R)-5-(4-chlorophenyl)-4-phenyl-2-thioxooxazolidin-4-yl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 4 h / 0 °C

2.1: ammonium hydroxide / water / 0.33 h / 20 °C

3.1: triethylamine; carbon disulfide / dichloromethane / 2 h / 0 °C

3.2: 2 h / 20 °C

4.1: C₃₂H₂₈F₆N₄O₃ / Dimethyl ether / 48 h / 30 °C

With carbon disulfide; ammonium hydroxide; C₃₂H₂₈F₆N₄O₃; triethylamine; In tetrahydrofuran; Dimethyl ether; dichloromethane; water; 4.1: |Aldol Addition;
DOI:10.1002/anie.201308514