Technology Process of benzyl [2-amino-1-(3,4-difluorophenyl)ethyl]carbamate
There total 6 articles about benzyl [2-amino-1-(3,4-difluorophenyl)ethyl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; diethyl ether;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ammonium acetate / ethanol / 20 h / Inert atmosphere; Reflux
2.1: N,N-dimethyl-formamide / 135 °C
3.1: triethylamine; diphenyl phosphoryl azide / toluene / 3.5 h / 20 °C / Inert atmosphere
3.2: Reflux
4.1: methylamine / water / 60 °C
5.1: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 48 h / 20 °C
6.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C
With
hydrogenchloride; dmap; diphenyl phosphoryl azide; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide / 135 °C
2.1: triethylamine; diphenyl phosphoryl azide / toluene / 3.5 h / 20 °C / Inert atmosphere
2.2: Reflux
3.1: methylamine / water / 60 °C
4.1: N-ethyl-N,N-diisopropylamine; dmap / tetrahydrofuran / 48 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 20 °C
With
hydrogenchloride; dmap; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; toluene;
![benzyl tert-butyl [1-(3,4-difluorophenyl)ethane-1,2-diyl]biscarbamate](/Databaselist/images/loading.webp)
