2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Base Information

Chemical Name:2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide
CAS No.:171504-69-1
Molecular Formula:C₁₈H₂₃N₃O₃S
Molecular Weight:361.465
Hs Code.:

Synonyms:2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

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Chemical Property of 2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

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Technology Process of 2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

There total 11 articles about 2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171504-76-0
(4'S)-5,4'-Dimethyl-2'-phenethyl-4',5'-dihydro-2,4'-bioxazoyl-4-carboxylic acid methylamide

: 171504-69-1
2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Guidance literature:: With hydrogen sulfide; triethylamine; In methanol; for 72h; Yield given; Ambient temperature;
DOI:10.1016/0040-4039(95)01322-9

Reference yield:

: 819081-56-6
2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

: 171504-69-1
2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP, bromotripyrrolidinophosphonium hexafluorophosphate / CH₂Cl₂

2: H₂ / Pd(OH)2 / methanol

3: Ph₃P, DIAD / tetrahydrofuran

4: H₂S, NEt₃ / methanol / 22 °C

With dmap; di-isopropyl azodicarboxylate; hydrogen sulfide; hydrogen; triethylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-1997-681

Reference yield:

: 171011-99-7
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

: 171504-69-1
2-<(1S)-2-hydroxy-1-methyl-1-<<3-(phenylthio)propionyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: Bu₄NF / dioxane

2: DMAP, bromotripyrrolidinophosphonium hexafluorophosphate / CH₂Cl₂

3: H₂ / Pd(OH)2 / methanol

4: Ph₃P, DIAD / tetrahydrofuran

5: H₂S, NEt₃ / methanol / 22 °C

With dmap; di-isopropyl azodicarboxylate; hydrogen sulfide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1055/s-1997-681