2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

Base Information

Chemical Name:2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide
CAS No.:819081-56-6
Molecular Formula:C₁₆H₂₁N₃O₃
Molecular Weight:303.361
Hs Code.:

Synonyms:2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

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Chemical Property of 2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

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Technology Process of 2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

There total 9 articles about 2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 171011-99-7
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methylamide

: 819081-56-6
2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

Guidance literature:: With tetrabutyl ammonium fluoride; In 1,4-dioxane; for 12h; Heating;
DOI:10.1021/jo00127a030

Reference yield:

: 168553-64-8
(S)-3-Benzyloxy-2-methyl-2-(2-trimethylsilanyl-ethanesulfonylamino)-propionic acid

: 819081-56-6
2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: DMAP, bromotripyrrolidinophosphonium hexafluorophosphate

2: Dess-Martin reagent

3: Ph₃P, I₂, NEt₃

4: methanol

5: Bu₄NF / dioxane

With dmap; tetrabutyl ammonium fluoride; iodine; Dess-Martin periodane; triethylamine; triphenylphosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; methanol;
DOI:10.1055/s-1997-681

Reference yield:

: 171011-86-2
2-<(1S)-2-(Benzyloxy)-1-methyl-1-<<<2-(trimethylsilyl)ethyl>sulfonyl>amino>ethyl>-5-methyloxazole-4-carboxylic acid methyl ester

: 819081-56-6
2-((S)-1-Amino-2-benzyloxy-1-methyl-ethyl)-5-methyl-oxazole-4-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol

2: Bu₄NF / dioxane

With tetrabutyl ammonium fluoride; In 1,4-dioxane; methanol;
DOI:10.1055/s-1997-681