diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

Base Information

Chemical Name:diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)
CAS No.:1425510-16-2
Molecular Formula:C₄₃H₄₃Br₂F₃N₆O₉
Molecular Weight:1004.65
Hs Code.:

diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

Synonyms:diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

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Chemical Property of diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

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Technology Process of diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

There total 5 articles about diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1425510-15-1
N-(4-((2,6-bis(bromomethyl)pyridin-4-yl)ethynyl)phenyl)-2,2,2-trifluoroacetamide

: 1444764-27-5
ethyl-2-((4-bromo-6-(carboxyethyl)-pyridine-2-yl)methylenenitrilo)acetate

: 1425510-16-2
diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 27h;

Reference yield:

: 95650-58-1
N-(4-ethynylphenyl)-2,2,2-trifluoroacetamide

: 1425510-16-2
diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 19 h / 55 °C / Inert atmosphere

2: phosphorus tribromide / chloroform / 20 h / 60 °C

3: potassium carbonate / acetonitrile / 27 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; phosphorus tribromide; potassium carbonate; triethylamine; In tetrahydrofuran; chloroform; acetonitrile;

Reference yield:

: 178321-87-4
4-bromo-6-(bromomethyl)picolinic acid ethyl ester

: 1425510-16-2
diethyl 6,6'-((((4-((4-trifluoroacetamidophenyl)ethynyl)-pyridine-2,6-diyl)bis(methylene))bis((2-ethoxy-2-oxoethyl)azanediyl))bis(methylene))-bis(4-bromopicolinate)

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2: potassium carbonate / acetonitrile / 27 h / 70 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In acetonitrile;