[1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Base Information

Chemical Name:[1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide
CAS No.:618448-72-9
Molecular Formula:C₁₇H₂₇NO₂
Molecular Weight:277.407
Hs Code.:

Synonyms:[1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

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Technology Process of [1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

There total 2 articles about [1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 513-38-2
Isobutyl iodide

: 192060-67-6
(1R,2R)-(-)-pseudoephedrinepropionamide

: 618448-72-9
[1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Guidance literature:: With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 13h;
DOI:10.1021/jo034738l

Reference yield: 80.0%

: 513-38-2
Isobutyl iodide

: C₁₃H₁₇NO₂^(2-)*2Na⁽¹⁺⁾

: 618448-72-9
[1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Guidance literature:: In tetrahydrofuran; at -40 ℃; for 2h; Temperature; Solvent; stereoselective reaction;
DOI:10.1021/jacs.9b08176

Reference yield:

: 618448-72-9
[1R,2R(S)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

: (2S,3R,4S)-3-Benzyloxy-2,4,6-trimethyl-heptanal

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / LiAlH₄; ethyl acetate / hexane; tetrahydrofuran / 1 h / 0 °C

2: BF₃*Et₂O / tetrahydrofuran / 4 h / -78 °C

3: 99 percent / triflic acid / CH₂Cl₂; cyclohexane / 4 h / 20 °C

4: OsO₄; 4-methylmorpholine N-oxide; aq. NaIO₄ / dioxane / 1.5 h / 20 °C

With sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; ethyl acetate; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; cyclohexane;
DOI:10.1021/jo034738l