Technology Process of 3-(3-(but-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid
There total 14 articles about 3-(3-(but-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol; water;
for 7h;
Inert atmosphere;
Reflux;
DOI:10.1002/anie.201300683
- Guidance literature:
-
4-oxooct-7-ynoic acid;
With
tert-butylhypochlorite; ammonia;
In
methanol; tert-butyl alcohol;
at 20 ℃;
for 4h;
Microwave irradiation;
With
tert-butylhypochlorite;
In
methanol; tert-butyl alcohol;
at 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1002/adsc.202100679
- Guidance literature:
-
Multi-step reaction with 8 steps
1: toluene-4-sulfonic acid / toluene / 6 h / 120 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere
3: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C / Inert atmosphere
4: ammonia / dichloromethane / 16.25 h / -40 - 20 °C
5: triethylamine; iodine / dichloromethane / 4 h / 20 °C / Inert atmosphere
6: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
7: N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere
8: water; sodium hydroxide / methanol / 16 h / 90 °C / Inert atmosphere
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; ammonia; water; iodine; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
