3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Base Information

Chemical Name:3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide
CAS No.:1336962-17-4
Molecular Formula:C₄₁H₄₄F₃N₅O₂
Molecular Weight:695.828
Hs Code.:

Synonyms:3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Chemical Property of 3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

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Technology Process of 3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

There total 10 articles about 3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1336905-32-8
3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 41049-53-0,773012-60-5
1-phenylcyclopropylamine

: 1336962-17-4
3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane; for 16h; Reflux;

Reference yield:

: 77337-82-7
1-bromo-2-methoxy-4-nitrobenzene

: 1336962-17-4
3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen bromide / water / 20 h / Reflux

2.1: potassium carbonate / acetonitrile / 2 h / Reflux

3.1: nickel(II) chloride tetrahydrate / acetonitrile / 0.08 h / 0 °C

3.2: 0.08 h / 0 °C

4.1: ethanol / 1 h / Reflux

4.2: 19 h / 20 °C / Reflux

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

5.2: 1 h / 20 °C

6.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 6 h / Reflux

7.1: potassium carbonate / acetonitrile / 2 h / Reflux

8.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 120 °C

9.1: trifluoroacetic acid / acetonitrile; water / 1 h / Reflux

10.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; tetrahydrofuran / 16 h / Reflux

With N-Bromosuccinimide; oxalyl dichloride; hydrogen bromide; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride tetrahydrate; N,N-dimethyl-formamide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 52427-05-1
2-bromo-5-nitrophenol

: 1336962-17-4
3-(1,4'-bipiperidin-1'-ylmethyl)-6-cyano-7-[(1-methylethyl)oxy]-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / acetonitrile / 2 h / Reflux

2.1: nickel(II) chloride tetrahydrate / acetonitrile / 0.08 h / 0 °C

2.2: 0.08 h / 0 °C

3.1: ethanol / 1 h / Reflux

3.2: 19 h / 20 °C / Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

4.2: 1 h / 20 °C

5.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 6 h / Reflux

6.1: potassium carbonate / acetonitrile / 2 h / Reflux

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 120 °C

8.1: trifluoroacetic acid / acetonitrile; water / 1 h / Reflux

9.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; tetrahydrofuran / 16 h / Reflux

With N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride tetrahydrate; N,N-dimethyl-formamide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;