Technology Process of (4S,6S)-4-allyl-6-(2-(4-methoxy-benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxane
There total 5 articles about (4S,6S)-4-allyl-6-(2-(4-methoxy-benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
benzene;
at 23 ℃;
for 3.5h;
Inert atmosphere;
DOI:10.1021/ol2003836
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: titanium(IV) isopropylate; (-)-diethyl tartrate / dichloromethane / 0.75 h / -20 °C / Inert atmosphere
1.2: 7 h / -20 °C / Inert atmosphere
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; methanol; toluene / 18.17 h / 0 - 23 °C / Inert atmosphere
3.1: camphor-10-sulfonic acid / benzene / 3.5 h / 23 °C / Inert atmosphere
With
titanium(IV) isopropylate; (-)-diethyl tartrate; camphor-10-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; dichloromethane; toluene; benzene;
1.1: Sharpless epoxidation / 1.2: Sharpless epoxidation;
DOI:10.1021/ol2003836
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diethyl ether / 3 h / -78 °C / Inert atmosphere
1.2: -78 - 23 °C / Inert atmosphere
2.1: titanium(IV) isopropylate; (-)-diethyl tartrate / dichloromethane / 0.75 h / -20 °C / Inert atmosphere
2.2: 7 h / -20 °C / Inert atmosphere
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; methanol; toluene / 18.17 h / 0 - 23 °C / Inert atmosphere
4.1: camphor-10-sulfonic acid / benzene / 3.5 h / 23 °C / Inert atmosphere
With
titanium(IV) isopropylate; (-)-diethyl tartrate; camphor-10-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; benzene;
2.1: Sharpless epoxidation / 2.2: Sharpless epoxidation;
DOI:10.1021/ol2003836
