(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

Base Information

Chemical Name:(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate
CAS No.:726190-72-3
Molecular Formula:C₂HF₃O₂*C₂₄H₂₆BrClFN₅O₅
Molecular Weight:712.88
Hs Code.:

(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

Synonyms:(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

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Chemical Property of (β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

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Technology Process of (β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

There total 1 articles about (β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride

: 726190-70-1
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

: 726190-72-3
(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

Guidance literature:: 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at -5 - 20 ℃; for 2h;

ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride; With 4-methyl-morpholine; In DMF (N,N-dimethyl-formamide); at 20 ℃; pH=7;

Reference yield: 59.0%

: 726190-72-3
(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

: 76-05-1
trifluoroacetic acid

: (β¹R)-3-bromo-5-chloro-β-[[2-[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)-amino]-benzoyl]amino]acetyl]amino]-2-hydroxy-benzene-propionic acid trifluoroacetate salt

Guidance literature:: (β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate; With lithium hydroxide; water; at 20 ℃; for 2h;

trifluoroacetic acid; pH=2;