3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

Base Information

Chemical Name:3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride
CAS No.:726190-70-1
Molecular Formula:C₁₁H₁₂FN₃O₂*ClH
Molecular Weight:273.695
Hs Code.:

Synonyms:3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

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Chemical Property of 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

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Technology Process of 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

There total 1 articles about 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 406682-48-2
N-(5-fluoro-1,4,5,6-tetrahydropyrimidin-2-yl)-3-aminobenzoic acid

: 726190-70-1
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 10 ℃; for 1h;

Reference yield: 64.0%

: ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride

: 726190-70-1
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

: 726190-72-3
(β1R)-3-bromo-5-chloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

Guidance literature:: 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at -5 - 20 ℃; for 2h;

ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride; With 4-methyl-morpholine; In DMF (N,N-dimethyl-formamide); at 20 ℃; pH=7;

Reference yield: 27.0%

: ethyl (3R)-3-(N-Gly)amino-3-(3,5-dichloro-2-hydroxyphenyl)propionate hydrochloride

: 726190-70-1
3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride

: (β1R)-3,5-dichloro-β-[[[[3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoyl]amino]acetyl]amino]-2-hydroxybenzenepropanoic acid ethyl ester monotrifluoroacetate

Guidance literature:: 3-[(5-fluoro-1,4,5,6-tetrahydro-2-pyrimidinyl)amino]benzoic acid monohydrochloride; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at -5 - 20 ℃; for 2h;

ethyl (3R)-3-(N-Gly)amino-3-(3,5-dichloro-2-hydroxyphenyl)propionate hydrochloride; With 4-methyl-morpholine; In DMF (N,N-dimethyl-formamide); at 20 ℃; pH=7;