8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol

Base Information

• Chemical Name: 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol
• CAS No.: 913295-42-8
• Molecular Formula: C₂₁H₁₈F₃N₃O
• Molecular Weight: 385.389

Synonyms:8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol

Chemical Property of 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol

Chemical Property:

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Technology Process of 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol

There total 1 articles about 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine (659729-09-6) + 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol (624729-66-4) → 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol (913295-42-8)

Guidance literature:

In ethanol; at 160 ℃; microvawe irradiation;

DOI:10.1016/j.bmcl.2008.02.022

Reference yield: 82.0%

8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol (913295-42-8) → 5-Bromo-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (913295-79-1)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.02.022

Reference yield: 16.0%

8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol (913295-42-8) → 7-chloro-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (913295-82-6) + 5-chloro-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (913295-81-5) + C21H16Cl2F3N3O

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2008.02.022

upstream raw materials:

4-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine

8-amino-1,2,3,4-tetrahydronaphthalen-2-ol

Downstream raw materials:

5-Bromo-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

5-Chloro-8-(5-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

7-chloro-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

5-chloro-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

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