N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide

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Chemical Name:N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide
CAS No.:1226861-52-4
Molecular Formula:C₂₇H₂₇F₃N₆O₃
Molecular Weight:540.545
Hs Code.:

Synonyms:N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide

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Chemical Property of N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide

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Technology Process of N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide

There total 2 articles about N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3-(pyrrolidin-1-yl)propanoyl chloride

: 1225380-81-3
C₂₀H₁₆F₃N₅O₂

: 1226861-52-4
N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 76234-38-3
β-(1-Pyrrolidinyl)-Propionic Acid

: 1226861-52-4
N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 16 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;