76234-38-3

Basic information

• Product Name: 3-PYRROLIDIN-1-YL-PROPIONIC ACID HCL
• Synonyms: RARECHEM AL BO 0351;3-(PYRROLIDIN-1-YL)PROPANOIC ACID;3-PYRROLIDIN-1-YL-PROPIONIC ACID;3-PYRROLIDIN-1-YL-PROPIONIC ACID HCL;3-PYRROLIDIN-1-YL-PROPIONIC ACIDHYDROCHLORIDE;AKOS BC-0367;1-PYRROLIDINEPROPANOIC ACID;3-(1-PYRROLIDINYL)PROPIONIC ACID
• CAS NO: 76234-38-3
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.19
• Mol File: 76234-38-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 162-172°C
• Boiling Point: 263.7 °C at 760 mmHg
• Flash Point: 113.3 °C
• Appearance: /
• Density: 1.114 g/cm³
• Vapor Pressure: 0.00297mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.83±0.10(Predicted)
• CAS DataBase Reference: 3-PYRROLIDIN-1-YL-PROPIONIC ACID HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRROLIDIN-1-YL-PROPIONIC ACID HCL(76234-38-3)
• EPA Substance Registry System: 3-PYRROLIDIN-1-YL-PROPIONIC ACID HCL(76234-38-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 76234-38-3(Hazardous Substances Data)

Usage

Uses

3-Pyrrolidin-1-ylpropanoic Acid is used to prepare acylaminophenothiazines as neuroprotective agents.

InChI:InChI=1/C7H13NO2/c9-7(10)3-6-8-4-1-2-5-8/h1-6H2,(H,9,10)

Upstream product

• 123-75-1 pyrrolidine 
• 79-10-7 acrylic acid 
• 22041-21-0 methyl 3-(pyrrolidin-1-yl)propanoate 
• 6317-35-7 ethyl 3-tetrahydro-1H-1-pyrrolilpropanoate 

Downstream Products

• 1309863-61-3 N'-{2-[(4-methoxy-2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide 
• 1309863-59-9 N'-{2-[(2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide 
• 1309863-60-2 N'-{2-[(4-chloro-2-nitrophenyl)thio]phenyl}-3-(pyrrolidin-1-yl)propanehydrazide 
• 1392003-85-8 (3aR,4S,7aR)-4-(3-pyrrolidin-1-yl-propionyloxy)-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester 
• 1226861-61-5 N-{4-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide 
• 1226861-52-4 N-{3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]phenyl}-3-(pyrrolidin-1-yl)propanamide 

Relevant articles and documents

Synthesis of 3-(2-aminoethyl)-5-hydroxy-1H-pyrazole derivatives

Treatment of β-keto ester 8 with hydrazines 9a-g gave 1'-substituted tert-butyl 2-(5-hydroxy-1Hpyrazol- 3-yl)ethylcarbamates 10a-e and 2-(5-oxo-2,5-dihydro-1H-pyrazol-3-yl)ethylcarbamates 11f,g. Acidolytic deprotection of 10b,c afforded the corresponding 3-(2-aminoethyl)-5-hydroxy- 1H-pyrazoles 6b,c in good yields. Acylation of 6 gave either the N-acyl compounds 12b,c and 13c, or the N,O-diacyl derivative 14. Next, three N,N-dialkyl analogues 15a,b and 26c were prepared from dimethyl acetone-1,3-dicarboxylate 21 via condensation with hydrazines 9a and 9h followed by hydrolysis of the esters 22a,b, amidation of the carboxylic acids 23a,b, and reduction of the tertiary carboxamides 24a and 25b,c. ARKAT-USA, Inc.

Synthesis, IR and NMR studies of zwitterionic ω-(1-pyrrolidine)alkanocarboxylic acids and their N-methyl derivatives

Six ω-(1-pyrrolidine)alkanocarboxylic acid hydrohalides [C4H8N+H(CH2)(n)COOH · X-] and 1-(ω-carboxyalkyl)-1-methyl-pyrrolidinium hydrohalides [C4H8N+CH3(CH2)(n)COOH · X- (n = 1,2,3,4,5,10)] and their sodium and inner salts were synthesized, respectively. IR, 1H and 13C NMR spectra were analyzed with regard to the increasing distance effect on the interaction between the positive nitrogen atom with the negative carboxylic group. The configuration of the pyrrolidine ring was also discussed.

Chartreusin derivatives and salts thereof

This invention relates to a novel chartreusin derivative of the general formula (I): STR1 and a salt thereof. This chartreusin derivative and a salt thereof have an excellent antitumor activity, which is exhibited even when the site of cancer inoculation