(2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

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Chemical Name:(2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid
CAS No.:851577-59-8
Molecular Formula:C₂₆H₃₄N₂O₄
Molecular Weight:438.567
Hs Code.:

Synonyms:(2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

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Chemical Property of (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

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Technology Process of (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

There total 10 articles about (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 851577-57-6
ethyl (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoate

: 851577-59-8
(2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

Guidance literature:: ethyl (2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoate; With sodium hydroxide; water; In tetrahydrofuran; at 60 ℃; for 12h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 907611-08-9
5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile

: 851577-59-8
(2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 1 h / 80 °C

2.1: ammonium cerium (IV) nitrate / water; acetone

3.1: ammonia; hydrogen / tetrahydrofuran; methanol / 3750.38 Torr

4.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

4.2: 15 h / 0 - 20 °C

5.1: sodium hydroxide / tetrahydrofuran / 20 °C

6.1: manganese(IV) oxide / tetrahydrofuran / 19 h / 20 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

7.2: 0.75 h / 20 °C

8.1: sodium hydroxide / tetrahydrofuran / 12 h / 60 °C

With manganese(IV) oxide; ammonium cerium (IV) nitrate; ammonia; hydrogen; sodium hydride; diisobutylaluminium hydride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; acetone; toluene; mineral oil; 7.1: Horner-Wadsworth-Emmons olefination / 7.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm101236h

Reference yield:

: 851577-39-4
methyl 5-cyano-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)-1,4-dihydropyridine-3-carboxylate

: 851577-59-8
(2E)-3-[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]prop-2-enoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium cerium (IV) nitrate / water; acetone

2.1: ammonia; hydrogen / tetrahydrofuran; methanol / 3750.38 Torr

3.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

3.2: 15 h / 0 - 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 20 °C

5.1: manganese(IV) oxide / tetrahydrofuran / 19 h / 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

6.2: 0.75 h / 20 °C

7.1: sodium hydroxide / tetrahydrofuran / 12 h / 60 °C

With manganese(IV) oxide; ammonium cerium (IV) nitrate; ammonia; hydrogen; sodium hydride; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; methanol; water; acetone; toluene; mineral oil; 6.1: Horner-Wadsworth-Emmons olefination / 6.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/jm101236h