907611-08-9

Basic information

• Product Name: 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile
• Synonyms: 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile
• CAS NO: 907611-08-9
• Molecular Weight: 227.306
• Mol File: 907611-08-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile(907611-08-9)
• EPA Substance Registry System: 5-methyl-2-[(4-methylphenyl)methylidene]-3-oxohexanenitrile(907611-08-9)

Safety Data

• Hazardous Substances Data: 907611-08-9(Hazardous Substances Data)

Upstream product

• 64373-43-9 5-methyl-3-oxo-hexanenitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 556-24-1 methyl 3-methylbutanoate 

Downstream Products

• 851578-66-0 methyl 5-cyano-2-ethyl-6-isobutyl-4-(4-methylphenyl)-1,4-dihydropyridine-3-carboxylate 
• 1262861-31-3 tert-butyl {[5-{2-[(3-carbamoylphenyl)amino]-2-oxoethyl}-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate 
• 1262861-32-4 tert-butyl {[5-{2-[(3-acetylphenyl)amino]-2-oxoethyl}-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl]methyl}carbamate 
• 1262861-33-5 tert-butyl {[6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)-5-(2-{[3-(methylsulfanyl)phenyl]amino}-2-oxoethyl)-pyridin-3-yl]methyl}carbamate 
• 907611-40-9 tert-butyl {[6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)-5-(2-{[3-(methylsulfonyl)phenyl]amino}-2-oxoethyl)-pyridin-3-yl]methyl}carbamate 
• 851586-42-0 methyl 4-({[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}amino)thiophene-3-carboxylate 
• 1262861-35-7 methyl N-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}glycinate 
• 851586-54-4 methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-L-prolinate 
• 907611-36-3 tert-butyl {[5-{2-[(2S)-2-carbamoylpyrrolidin-1-yl]-2-oxoethyl}-6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)-pyridin-3-yl]methyl}carbamate 
• 1262861-36-8 methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}-D-prolinate 
• 1262861-37-9 methyl 1-{[5-{[(tert-butoxycarbonyl)amino]methyl}-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridin-3-yl]-acetyl}pyrrolidine-3-carboxylate 
• 1262861-38-0 tert-butyl {[6-methyl-4-(4-methylphenyl)-2-(2-methylpropyl)-5-{2-[3-(methylsulfonyl)pyrrolidin-1-yl]-2-oxoethyl}-pyridin-3-yl]methyl}carbamate 
• 1262861-39-1 tert-butyl ({6-methyl-5-[2-(methylamino)-2-oxoethyl]-4-(4-methylphenyl)-2-(2-methylpropyl)pyridin-3-yl}methyl)-carbamate 

Relevant articles and documents

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

We have previously discovered nicotinic acid derivative 1 as a structurally novel dipeptidyl peptidase IV (DPP-4) inhibitor. In this study, we obtained the X-ray co-crystal structure between nicotinic acid derivative 1 and DPP-4. From these X-ray co-cryst

PYRIDYL ACETIC ACID COMPOUNDS

The present invention provides a compound represented by the formula (I): wherein R1 is a C?1-6#191 alkyl group optionally substituted by a C?3-10#191 cycloalkyl group, R2 is a C?2-6#191 alkyl group, R3 is a hydrogen atom, a C?1-6#191 alkyl group or a halogen atom, and X is -OR6 or -NR4R5 wherein R4 and R6 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R5 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted hydroxy group, or R4 and R5 optionally form, together with the adjacent nitrogen atom, an optionally substituted nitrogen-containing heterocycle, or a salt thereof. The compound of the present invention has a superior peptidase inhibitory action and is useful as an agent for the prophylaxis or treatment of diabetes and the like.