ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

Base Information

Chemical Name:ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate
CAS No.:1224598-17-7
Molecular Formula:C₂₂H₂₅ClN₃O₄P
Molecular Weight:461.885
Hs Code.:

Synonyms:ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

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Chemical Property of ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

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Technology Process of ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

There total 1 articles about ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1224598-15-5
2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

: 623-49-4
ethyl cyanoformate

: 1224598-17-7
ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

Guidance literature:: 2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

ethyl cyanoformate; In tetrahydrofuran; at 25 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol100453x

Reference yield: 81.0%

: 591-50-4
iodobenzene

: 1224598-17-7
ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

: 1224598-18-8
ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)-8-phenylquinoline-4-carboxylate

Guidance literature:: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; In tetrahydrofuran; at -40 ℃; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at -40 ℃; for 0.25h; Inert atmosphere;

iodobenzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at -40 - 25 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol100453x

Reference yield:

: 1224598-17-7
ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

: 106-95-6
allyl bromide

: C₂₅H₂₉ClN₃O₄P

Guidance literature:: ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; In tetrahydrofuran; at -40 ℃; Inert atmosphere;

allyl bromide; With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol100453x