2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

Base Information

Chemical Name:2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate
CAS No.:1224598-15-5
Molecular Formula:C₁₉H₂₁ClN₃O₂P
Molecular Weight:389.821
Hs Code.:

Synonyms:2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

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Chemical Property of 2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

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Technology Process of 2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

There total 1 articles about 2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 1224598-13-3
quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

: 1224598-15-5
2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

Guidance literature:: quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate; With bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex; In tetrahydrofuran; at -50 ℃; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at -40 ℃; for 0.25h; Inert atmosphere;

1-Chloro-4-iodobenzene; With trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at -40 - 25 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol100453x

Reference yield: 81.0%

: 1224598-15-5
2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

: 623-49-4
ethyl cyanoformate

: 1224598-17-7
ethyl 3-([bis(dimethylamino)phosphoryl]oxy)-2-(4-chlorophenyl)quinoline-4-carboxylate

Guidance literature:: 2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

ethyl cyanoformate; In tetrahydrofuran; at 25 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol100453x

Reference yield:

: 1224598-15-5
2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate

: 106-95-6
allyl bromide

: C₂₂H₂₅ClN₃O₂P

Guidance literature:: 2-(4-chlorophenyl)quinolin-3-yl N,N,N',N'-tetramethyldiamidophosphate; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

allyl bromide; With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol100453x