(3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

Base Information

Chemical Name:(3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one
CAS No.:516479-96-2
Molecular Formula:C₂₂H₂₇NO₆
Molecular Weight:401.459
Hs Code.:

Synonyms:(3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

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Chemical Property of (3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

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Technology Process of (3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

There total 5 articles about (3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: O,O-cyclohexylidene-D-glyceraldehyde N-4-methoxyphenylimine

: 516479-57-5
S-2-pyridylthio 5-(4-methoxyphenoxy)pentanoate

: 516479-96-2
(3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

: 516479-67-7
(3R,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

Guidance literature:: S-2-pyridylthio 5-(4-methoxyphenoxy)pentanoate; With TEA; titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.333333h;

O,O-cyclohexylidene-D-glyceraldehyde N-4-methoxyphenylimine; In dichloromethane; at -78 - 20 ℃; for 18h;

With trifluoroacetic acid; In water; at 0 - 20 ℃; for 0.916667h;
DOI:10.1021/jo020617u

Reference yield:

: 542-28-9,26354-94-9
3,4,5,6-tetrahydro-2H-pyran-2-one

: 516479-96-2
(3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pTSA / 18 h / Heating

2.1: 90 percent / PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂ / 48 h / 20 °C

3.1: KOH / methanol; H₂O / 24 h / 20 °C

4.1: 97.5 percent / PPh₃ / CH₂Cl₂ / 15 h / 20 °C

5.1: titanium tetrachloride; TEA / CH₂Cl₂ / 0.33 h / -78 °C

5.2: CH₂Cl₂ / 18 h / -78 - 20 °C

5.3: 0.065 g / TFA / H₂O / 0.92 h / 0 - 20 °C

With potassium hydroxide; di-isopropyl azodicarboxylate; TEA; titanium tetrachloride; toluene-4-sulfonic acid; triphenylphosphine; In methanol; dichloromethane; water; 2.1: Mitsunobu reaction;
DOI:10.1021/jo020617u

Reference yield:

: 14273-92-8
methyl 5-hydroxypentanoate

: 516479-96-2
(3S,4R,4'S)-1-(4-methoxyphenyl)-3-[3-(4-methoxyphenoxy)prop-1-yl]-4-(1,2-dihydroxyethyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂ / 48 h / 20 °C

2.1: KOH / methanol; H₂O / 24 h / 20 °C

3.1: 97.5 percent / PPh₃ / CH₂Cl₂ / 15 h / 20 °C

4.1: titanium tetrachloride; TEA / CH₂Cl₂ / 0.33 h / -78 °C

4.2: CH₂Cl₂ / 18 h / -78 - 20 °C

4.3: 0.065 g / TFA / H₂O / 0.92 h / 0 - 20 °C

With potassium hydroxide; di-isopropyl azodicarboxylate; TEA; titanium tetrachloride; triphenylphosphine; In methanol; dichloromethane; water; 1.1: Mitsunobu reaction;
DOI:10.1021/jo020617u