4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol

Base Information

• Chemical Name: 4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol
• CAS No.: 688773-08-2
• Molecular Formula: C₃₇H₅₆O₆Si₂
• Molecular Weight: 653.019
• Mol file: 688773-08-2.mol

Synonyms:4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol

Chemical Property of 4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol

There total 1 articles about 4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-2-bromo-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-3-trimethylsilanyloxy-2'-(2-trimethylsilanyloxy-ethyl)-biphenyl → 4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol (688773-08-2)

Guidance literature:

4-benzyloxy-2-bromo-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-3-trimethylsilanyloxy-2'-(2-trimethylsilanyloxy-ethyl)-biphenyl; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h;

With hydrogenchloride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1055/s-2004-817754

Reference yield: 92.0%

methanesulfonyl chloride (124-63-0) + 4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol (688773-08-2) → methanesulfonic acid 2-[4'-benzyloxy-3'-hydroxy-4,5-dimethoxy-6'-(2-triisopropylsilanyloxy-ethyl)-2'-trimethylsilanyl-biphenyl-2-yl]-ethyl ester (688773-16-2)

Guidance literature:

With pyridine; at 25 ℃; for 0.5h;

DOI:10.1055/s-2004-817754

Reference yield:

4-benzyloxy-2'-(2-hydroxy-ethyl)-4',5'-dimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl-3-ol (688773-08-2) → (2-{2-[3,3-dimethoxy-4-oxo-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-cyclohexa-1,5-dienyl]-4,5-dimethoxy-phenyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 7 steps

1: 92 percent / pyridine / 0.5 h / 25 °C

2: NaN₃ / dimethylformamide / 5 h / 60 °C

3: NaH / dimethylformamide / 0.17 h / 0 °C

4: aq. PMe₃ / acetonitrile / 5 h / 25 °C

5: Et₃N / tetrahydrofuran / 1 h / 25 °C

6: H₂ / Pd/C / ethyl acetate; methanol / 1 h / 25 °C

7: (AcO)2IPh / 0.25 h / 25 °C

With pyridine; sodium azide; [bis(acetoxy)iodo]benzene; hydrogen; sodium hydride; triethylamine; trimethylphosphane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1055/s-2004-817754

Downstream raw materials:

methanesulfonic acid 2-[4'-benzyloxy-3'-hydroxy-4,5-dimethoxy-6'-(2-triisopropylsilanyloxy-ethyl)-2'-trimethylsilanyl-biphenyl-2-yl]-ethyl ester

2'-(2-azido-ethyl)-4-benzyloxy-3,4',5'-trimethoxy-6-(2-triisopropylsilanyloxy-ethyl)-2-trimethylsilanyl-biphenyl

{2-[4'-benzyloxy-4,5,3'-trimethoxy-6'-(2-triisopropylsilanyloxy-ethyl)-2'-trimethylsilanyl-biphenyl-2-yl]-ethyl}-carbamic acid tert-butyl ester