Technology Process of Methanesulfonic acid (1R,3S)-3-hydroxy-1-hydroxymethyl-5-phenylsulfanyl-pentyl ester
There total 9 articles about Methanesulfonic acid (1R,3S)-3-hydroxy-1-hydroxymethyl-5-phenylsulfanyl-pentyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -30 ℃;
DOI:10.1055/s-1997-1550
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 91 percent / H2 / Lindlar cat. / toluene / Ambient temperature
2: 88 percent / p-TsOH / toluene / Heating
3: 88 percent / 30percent hydrogen peroxide, 6 N sodium hydroxide / methanol / 0 °C
4: 83 percent / diphenyl diselenide, sodium borohydride, AcOH / ethanol
5: 95 percent / imidazole / dimethylformamide / Ambient temperature
6: 83 percent / lithium borohydride / tetrahydrofuran / 0 - 20 °C
7: 90 percent / tributylphosphine / pyridine / Ambient temperature
8: 96 percent / Et3N, DMAP / CH2Cl2 / Ambient temperature
9: 71 percent / boron tribromide / CH2Cl2 / -30 °C
With
1H-imidazole; dmap; sodium hydroxide; sodium tetrahydroborate; lithium borohydride; tributylphosphine; diphenyl diselenide; hydrogen; dihydrogen peroxide; boron tribromide; toluene-4-sulfonic acid; acetic acid; triethylamine;
Lindlar catalyst;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-1997-1550
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / 30percent hydrogen peroxide, 6 N sodium hydroxide / methanol / 0 °C
2: 83 percent / diphenyl diselenide, sodium borohydride, AcOH / ethanol
3: 95 percent / imidazole / dimethylformamide / Ambient temperature
4: 83 percent / lithium borohydride / tetrahydrofuran / 0 - 20 °C
5: 90 percent / tributylphosphine / pyridine / Ambient temperature
6: 96 percent / Et3N, DMAP / CH2Cl2 / Ambient temperature
7: 71 percent / boron tribromide / CH2Cl2 / -30 °C
With
1H-imidazole; dmap; sodium hydroxide; sodium tetrahydroborate; lithium borohydride; tributylphosphine; diphenyl diselenide; dihydrogen peroxide; boron tribromide; acetic acid; triethylamine;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1997-1550
