197520-87-9

Upstream product

• 14618-80-5 (R)-benzyl glycidol 
• 623-47-2 propynoic acid ethyl ester 
• 2930-05-4 Benzyloxymethyl-oxiran 

Downstream Products

• 389123-38-0 (Z)-(R)-6-Benzyloxy-5-hydroxy-3-methyl-hex-2-enoic acid ethyl ester 
• 1464823-09-3 (6R)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol 
• 197520-79-9 Methanesulfonic acid (1R,3S)-1-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-5-phenylsulfanyl-pentyl ester 
• 197520-86-8 [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-oct-7-yne-1-sulfinyl]-benzene 
• 197520-85-7 [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-oct-7-ynylsulfanyl]-benzene 
• 197520-78-8 (2R,4S)-1-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexan-2-ol 
• 197520-76-6 (4S,6R)-6-Benzyloxymethyl-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-one 
• 197520-80-2 Methanesulfonic acid (1R,3S)-3-hydroxy-1-hydroxymethyl-5-phenylsulfanyl-pentyl ester 
• 197520-77-7 (3R,5R)-6-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-hexane-1,5-diol 
• 197520-83-5 (4R,6S)-6-Methoxymethoxy-8-phenylsulfanyl-oct-1-yn-4-ol 
• 197520-82-4 (S)-2-((S)-2-Methoxymethoxy-4-phenylsulfanyl-butyl)-oxirane 
• 197520-84-6 (3S,5R)-1-Phenylsulfanyl-oct-7-yne-3,5-diol 
• 197520-81-3 (S)-1-(S)-Oxiranyl-4-phenylsulfanyl-butan-2-ol 
• 153255-52-8 (4S,6R)-6-Benzyloxymethyl-4-hydroxy-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

The mukaiyama type aldol reaction for the synthesis of: Trans-2,6-disubstituted tetrahydropyrans: Synthesis of diospongin a and b

An efficient synthesis protocol for the preparation of trans-2,6-disubstituted tetrahydropyrans by the reaction of 1-phenyl-1-triemthylsiloxyethylene with six membered cyclic hemiacetals in the presence of iodine is developed. This reaction proceeds smoothly under mild conditions employing a catalytic amount of molecular iodine. The feature of this novel conversion includes milder reaction conditions, broader substrate scope, functional group tolerance and good diastereoselectivity. The efficiency and practicality of the current method were successfully displayed in the total synthesis of diospongin A and B in good yields.

A Unified Procedure for Diastereo- and Enantiocontrolled Construction of Compactin Lactone and Calcitriol Enyne

A unified diastereo- and enantiocontrolled entry into compactin lactone, an essential structural moiety for the biological activity of compactin, and calcitriol enyne, an A-ring precursor of calcitriol, has been developed by use of the same stereocontrol