Technology Process of (R)-2-ethyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2,4,4-tetramethylpentanamide
There total 6 articles about (R)-2-ethyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2,4,4-tetramethylpentanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methyl-2-methylenebutanamide; tert.-butyl lithium;
With
methyllithium; lithium chloride;
In
tetrahydrofuran; formaldehyde diethyl acetal;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
In
tetrahydrofuran; formaldehyde diethyl acetal; pentane;
at -78 - -40 ℃;
for 0.333333h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; formaldehyde diethyl acetal; pentane;
at -40 ℃;
for 4h;
optical yield given as %de;
Inert atmosphere;
DOI:10.1002/anie.201200370
-
-
530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0
(1S,2S)-2-amino-1,2-diphenylethanol
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran; diethyl ether / 2.5 h / -40 - 23 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere
3.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 23 °C / Inert atmosphere
4.1: methyllithium; lithium chloride / tetrahydrofuran; formaldehyde diethyl acetal / 0.17 h / -78 °C / Inert atmosphere
4.2: 0.33 h / -78 - -40 °C / Inert atmosphere
4.3: 4 h / -40 °C / Inert atmosphere
With
lithium aluminium tetrahydride; methyllithium; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; diethyl ether; formaldehyde diethyl acetal; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200370
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere
2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 23 °C / Inert atmosphere
3.1: methyllithium; lithium chloride / tetrahydrofuran; formaldehyde diethyl acetal / 0.17 h / -78 °C / Inert atmosphere
3.2: 0.33 h / -78 - -40 °C / Inert atmosphere
3.3: 4 h / -40 °C / Inert atmosphere
With
lithium aluminium tetrahydride; methyllithium; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; diethyl ether; formaldehyde diethyl acetal; N,N-dimethyl-formamide;
DOI:10.1002/anie.201200370
