Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester
CAS No.:220509-17-1
Molecular Formula:C₂₁H₂₆O₇S
Molecular Weight:422.499
Hs Code.:

Synonyms:Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

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Chemical Property of Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

Chemical Property:

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Technology Process of Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

There total 8 articles about Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220509-15-9
Methanesulfonic acid (1R,2R,3R)-2,3-bis-benzyloxy-1-hydroxymethyl-4,4-dimethoxy-butyl ester

: 220509-17-1
Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

Guidance literature:: With hydrogenchloride; In methanol; Yield given;

Reference yield:

: 100-39-0
benzyl bromide

: 220509-17-1
Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / NaH, n-Bu₄NI / tetrahydrofuran

2: 1.) t-BuOK; 2.) fOrmic acid / 1.) DMSO, 100 deg C, 20 min; 2.) Et₂O

3: 71 percent / HCl / CHCl₃

4: DMAP, Et₃N / CH₂Cl₂ / 0 °C

5: CH₂Cl₂ / 5 h / 0 °C

6: Hg(ClO₄)2 / 1 h

7: HCl / methanol

With hydrogenchloride; dmap; formic acid; mercury(II) perchlorate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform;

Reference yield:

: 220509-07-9
(3R,4R,5R)-5-Allyloxymethyl-4-benzyloxy-2-methoxy-tetrahydro-furan-3-ol

: 220509-17-1
Methanesulfonic acid (3R,4R,5R)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / NaH, n-Bu₄NI / tetrahydrofuran

2: 1.) t-BuOK; 2.) fOrmic acid / 1.) DMSO, 100 deg C, 20 min; 2.) Et₂O

3: 71 percent / HCl / CHCl₃

4: DMAP, Et₃N / CH₂Cl₂ / 0 °C

5: CH₂Cl₂ / 5 h / 0 °C

6: Hg(ClO₄)2 / 1 h

7: HCl / methanol

With hydrogenchloride; dmap; formic acid; mercury(II) perchlorate; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform;