(S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

Base Information

Chemical Name:(S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol
CAS No.:177608-34-3
Molecular Formula:C₂₉H₃₈O₅Si
Molecular Weight:494.703
Hs Code.:

Synonyms:(S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

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Technology Process of (S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

There total 1 articles about (S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-ethane-1,2-diol

: (R)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

: 177608-34-3
(S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 5h;
DOI:10.1021/jo960085f

Reference yield:

: 177608-34-3
(S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

: (R)-Benzyloxycarbonylamino-(3,5-bis-benzyloxy-2-chloro-4-methoxy-phenyl)-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, diphenyl phosphorazidate, diethyl azodicarboxylate, 2.) PPh₃, H₂O / 1.) THF, 25 deg C, 2 h, 2.) 45 deg C, 21 h

2: 90 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 2 h / 25 °C

3: Bu₄NF / tetrahydrofuran / 2 h / 25 °C

4: 52 percent / NaHCO₃, KBr, TEMPO, Ca(OCl)2 / acetone; H₂O / 2 h / 0 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; calcium hypochlorite; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; sodium carbonate; triethylamine; triphenylphosphine; potassium bromide; diethylazodicarboxylate; In tetrahydrofuran; water; acetone;
DOI:10.1021/jo960085f

Reference yield:

: 177608-34-3
(S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol

: 177608-37-6
[(R)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, diphenyl phosphorazidate, diethyl azodicarboxylate, 2.) PPh₃, H₂O / 1.) THF, 25 deg C, 2 h, 2.) 45 deg C, 21 h

2: 90 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 2 h / 25 °C

With diphenyl phosphoryl azide; water; sodium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water;
DOI:10.1021/jo960085f