5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate
CAS No.:174221-81-9
Molecular Formula:C₃₂H₂₈Cl₃N₃O₇
Molecular Weight:672.949
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 545-06-2
trichloroacetonitrile

: 173170-12-2
2,2'-O-anhydro-1-<5'-O-(4,4'-dimethoxytrityl)-β-D-arabinofuranosyl>uracil

: 174221-81-9
5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

Guidance literature:: With sodium hydride; In 1,4-dioxane; for 16h; Ambient temperature;
DOI:10.1021/jo9510548

Reference yield:

: 3736-77-4
2,2'-Anhydrouridine

: 174221-81-9
5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP; pyridine / 16 h

2: Et₃N / 24 h / Heating

With pyridine; dmap; triethylamine;
DOI:10.1021/ol049366x

Reference yield:

: 58-96-8
uridine

: 174221-81-9
5'-O-(4,4'-dimethoxytrityl)-2,2'-O-anhydro-1-(β-D-arabinofuranosyl)uracil 3'-O-trichloroacetimidate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / diphenyl carbonate, sodium bicarbonate / dimethylformamide / 4.5 h / 110 - 120 °C

2: 56 percent / DMAP / pyridine / 16 h / Ambient temperature

3: 39 percent / NaH / dioxane / 16 h / Ambient temperature

With bis(phenyl) carbonate; dmap; sodium hydride; sodium hydrogencarbonate; In 1,4-dioxane; pyridine; N,N-dimethyl-formamide;
DOI:10.1021/jo9510548