Technology Process of N-{3-[(1R,2S,7R,8S)-3-(3,4-difluorobenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide
There total 14 articles about N-{3-[(1R,2S,7R,8S)-3-(3,4-difluorobenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-N-methylmethanesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / 5%-palladium/activated carbon / ethanol; water / 8 h / 55 °C / Industry scale
2.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale
3.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale
4.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale
4.2: 0 °C / Industry scale
5.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h
5.2: 4 h / 25 °C
5.3: 16 h / 50 °C
6.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C
With
4-methyl-morpholine; pyridine; water; hydrogen; potassium carbonate; sodium hydroxide;
5%-palladium/activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trichlorophosphate / sulfolane / 80 - 120 °C
1.2: 10 - 95 °C
1.3: 25 - 80 °C / pH 6 - 8
2.1: hydrogen / 5%-palladium/activated carbon / ethanol; water / 8 h / 55 °C / Industry scale
3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale
4.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale
5.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale
5.2: 0 °C / Industry scale
6.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h
6.2: 4 h / 25 °C
6.3: 16 h / 50 °C
7.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C
With
4-methyl-morpholine; pyridine; water; hydrogen; potassium carbonate; sodium hydroxide; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; sulfolane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
![N-{3-[(1R,2S,7R,8S)-3-(3,4-difluorobenzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}methanesulfonamide](/Databaselist/images/loading.webp)
